Antimicrobial resistance of methicillin-resistant coagulase negative staphylococcal species in two government hospitals in Kuantan, Malaysia

The emergence of nosocomial infections caused by CoNS has led clinicians and researchers to reconsider the role methicillin-resistant (MR-CoNS) as important agents infections. This study was conducted on clinical isolates MR-CoNS obtained from inpatients in Hospital Tengku Ampuan Afzan (HTAA) International Islamic University Malaysia Medical Center (IIUM-MC) determine their antimicrobial resistance profile. were cultured samples blood, tissues, swabs. Forty (33 4 3 swabs) collected through venepuncture, biopsy, swabbing techniques respectively, processed conventional cultural, biochemical methods susceptibility tests. Methicillin- vancomycin-resistance profile performed E-test broth micro-dilution methods. Of 40 isolates, 38 identified be (MIC ³ 0.5 µg/mL). remaining 2 considered susceptible methicillin ≤ 0.25). All found vancomycin (MIC=1-4 also tested for phenotypic using Kirby Bauer disc diffusion method. Resistance rates linezolid, erythromycin, ciprofloxacin, ceftaroline 100%. trimethoprim-sulfamethoxazole, teicoplanin, clindamycin 82.5%, 92.5%, 97.5% respectively. Thus, all revealed multi-drug profiles more than antimicrobials; highest being 9 antibiotics, except one isolate swab. points toward need periodic antibiogram surveillance they are cause difficult treat